Parks' contemporary drama offers a modern take on The Scarlet Letter through the lens of a homeless family living in the inner city. Centering around a matriarch of five named Hester, In the Blood details her struggles to improve both herself and the lives of her children in the face of impossible choices and seemingly insurmountable obstacles. Punctuated by endearing comedic moments amid Hester's arduous journey, In the Blood is frank study of poverty, femininity, and race in America.